selected publications


Walenta L, Fleck D, Fröhlich /, von Eysmondt H, Arnold G, Spehr J, Schwarzer JU, Köhn F-M, Spehr M, Mayerhofer A (2018) ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation. Scientific Reports 8: 1431.   PubMed
Unger J, Mansour M, Kopazka M, Gronloh N, Spehr M, Merhof D. An Unsupervised Learning Approach for Tracking Mice in an Enclosed Area. BMC Bioinformatics 18(1): 272.   PubMed
Henkel B, Bintig W, Bhat S, Spehr M, Neuhaus EM (2016) NHERF1 in Microvilli of Vomeronasal Sensory Neurons. Chemical Senses 42: 25-35.144.   PubMed
Gorin M, Tsitoura C, Kahan A, Watznauer K, Drose DR, Arts M, Mathar R, O'Connor S, Hanganu-Opatz IL, Ben-Shaul Y, Spehr M (2016) Interdependent conductances drive infra-slow intrinsic rhythmogenesis in a subset of accessory olfactory bulb projection neurons. The Journal of Neuroscience 36: 3127-3144.
Fleck D, Mundt N, Bruentgens F, Geilenkirchen P, A Machado P, Veitinger T, Veitinger S, Engelhardt CH, Oldiges M, Spehr J, Spehr M (2016) Distinct purinergic signaling pathways in prepubescent mouse spermatogonia. The Journal of General Physiology 148: 253-271.  PubMed
Cichy A, Ackels T, Tsitoura C, Kahan A, Gronloh N, Söchtig M, Engelhardt CH, Ben-Shaul Y, Müller F, Spehr J, Spehr M (2015) Extracellular pH regulates excitability of vomeronasal sensory neurons. The Journal of Neuroscience 35: 4025-4039. PubMed
Bitzenhofer SH, Sieben K, Siebert KD, Spehr M, Hanganu-Opatz IL (2015) Oscillatory activity in developing prefrontal networks results from theta-gamma modulated synaptic inputs. Cell Reports 3: 486-497. PubMed
Henkel B, Drose D, Ackels T, Oberland S, Spehr M, Neuhaus EM (2014) Coexpression of Anoctamins in cilia of olfactory sensory neurons. Chemical Senses 40: 73-87.
Oberland S, Ackels T, Gaab S, Pelz T, Spehr J, Spehr M, Neuhaus EM (2015) CD36 is involved in oleic acid detection by the murine olfactory system. Front. Cell. Neurosci. 9: 366. doi: 10.3389/fncel.2015.00366. PubMed
Kaur AW, Ackels T, Kuo T, Cichy A, Dey S, Hays C, Kateri M, Logan DW, Marton TF, Spehr M and Stowers L (2014) Murine Pheromone Proteins Constitute a Context-Dependent Combinatorial Code Governing Multiple Social Behaviors. Cell 157: 676-88 PubMed
Ackels T, von der Weid B, Rodriguez I and Spehr M (2014)
Physiological characterization of formyl peptide receptor expressing cells in the mouse vomeronasal organ. Front. Neuroanat., doi: 10.3389/fnana.2014.00134
2012 - 2013
Ferrero DM, Moeller LM, Osakada T, Horio N, Li Q, Roy DS, Cichy A, Spehr M, Touhara K, Liberles SD (2013) A juvenile mouse pheromone inhibits sexual behavior through the vomeronasal system. Nature, doi:10.1038/nature12579. PubMed

Dietzel E, Wessling J, Floehr J, Schäfer C, Ensslen S, Denecke B, Rösing B, Neulen J, Veitinger T, Spehr M, Tropartz T, Tolba R, Renne R, Egert A, Schorle H, Gottenbusch Y, Hildebrand A, Yiallouros I, Stöcker W, Weiskirchen R, Jahnen-Dechent W (2013) Fetuin-B, a liver-derived plasma protein is essential for fertilization. Dev. Cell 25, 106–112.

Fluegge D, Moeller LM, Cichy A, Gorin M, Weth A, Veitinger S, Cainarca S, Lohmer S, Corrazza S, Neuhaus EM, Baumgartner W, Spehr J, Spehr M (2012) Mitochondrial Ca Mobilization is a key element in olfactory signaling. Nature Neuroscience 15: 754-762. PubMed
Spehr J, Gelis L, Osterloh M, Oberland S, Hatt H, Spehr M, Neuhaus EM (2011) G-protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. J. Biol. Chem. 286: 13184-13192. PubMed
Veitinger T, Riffell JR, Veitinger S, Nascimento JM, Triller A, Chandsawangbhuwana C, Schwane K, Geerts A, Wunder F, Berns MW, Neuhaus EM, Zimmer RK§, Spehr M§, Hatt H§. (2011) Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. J. Biol. Chem. 286: 17311-17325. § shared senior authorship
Ferrero DM, Lemon JK, FlueggeD, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, Liberles SD (2011) Detection and avoidance of a carnivore odor by prey. PNAS 108: 11235-11240. PubMed
Veitinger S, Veitinger T, Cainarca S, Fluegge D, Engelhardt CH, Lohmer S, Hatt H, Corrazza S, Spehr J, Neuhaus EM, Spehr M (2011) Mitochondrial Ca Mobilization in Purinergic Mouse Sertoli Cell Signaling. J. Physiol. 589: 5033–5055. PubMed
2009 - 2010
Hagendorf S, Fluegge D, Engelhardt C, Spehr M (2009). Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels. The Journal of Neuroscience 29: 206-221. PubMed
Spehr J, Hagendorf S, Weiss J, Spehr M, Leinders-Zufall T, Zufall F (2009) Ca2+-calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ. The Journal of Neuroscience 29:2125-2135. PubMed
Spehr M and Munger SD (2009) Olfactory receptors: GPCRs and beyond. The Journal of Neurochemistry 109: 1570-1583. PubMed
Rivière S, Challet L, Fluegge D, Spehr M, Rodriguez I (2009) Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors. Nature 459: 574-577. PubMed
2006 - 2008
Mashukova A, Spehr M, Hatt H, Neuhaus EM (2006) β-arrestin2-mediated internalization of mammalian odorant receptors. The Journal of Neuroscience 26: 9902-9912. PubMed
Spehr M, Kelliher KR, Li XH, Boehm T, Leinders-Zufall T, Zufall F (2006) Essential role of the main olfactory system in social recognition of MHC class I peptides. The Journal of Neuroscience 26: 1961-1970. PubMed
Kelliher KR§, Spehr M§, Leinders-Zufall T, Zufall F (2006) Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing. Eur. J. Neurosci. 23: 3385-3390.
§ authors contributed equally
2001 - 2005

Spehr M, Wetzel CH, Hatt H, Ache BW (2002) 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron 33: 731-773.


Spehr M, Hatt H, Wetzel CH (2002) Arachidonic acid plays a role in rat vomeronasal signal transduction. The Journal of Neuroscience 22: 8429-8437.


Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H (2003) Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 299: 2054-2058.


Spehr M, Schwane K, Riffell JA, Barbour J, Zimmer RK, Neuhaus EM, Hatt H (2004) Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. J. Biol. Chem. 279: 40194-40203. PubMed
Spehr M, Schwane K, Heilmann S, Gisselmann G, Hummel T, Hatt H (2004) Dual capacity of a human olfactory receptor. Current Biology 14: 832-833. PubMed