Prof. Dr. Marc Spehr

 

Marc Spehr Position:
Arbeitsgruppenleiter
VNO
Arbeitsgebiet:
Neurophysiologie und Reproduktionsbiologie
Methoden:
Elektrophysiologie, Life-Cell Imaging, Histochemie, Konfokalmikroskopie

Kontakt:
m.spehr (at) sensorik.rwth-aachen.de

Tel.: +49 (0)241/80-20802

Fax: +49 (0)241/80-22802

ResearchGate

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ausgewählte Publikationen:  
Fleck D, Mundt N, Bruentgens F, Geilenkirchen P, A Machado P, Veitinger T, Veitinger S, Engelhardt CH, Oldiges M, Spehr J, Spehr M (2016) Distinct purinergic signaling pathways in prepubescent mouse spermatogonia. The Journal of General Physiology 148: 253-271.
 
Gorin M*, Tsitoura C*, Kahan A, Watznauer K, Drose DR, Arts M, Mathar R, O'Connor S, Hanganu-Opatz IL, Ben-Shaul Y, Spehr M (2016) Interdependent conductances drive infra-slow intrinsic rhythmogenesis in a subset of accessory olfactory bulb projection neurons. The Journal of Neuroscience 36: 3127-3144.
 
Cichy A, Ackels T, Tsitoura C, Kahan A, Gronloh N, Söchtig M, Engelhardt C, Ben-Shaul Y, Müller F, Spehr J and Spehr M (2015). HCN channels mediate proton-dependent signaling in the mouse vomeronasal organ. The Journal of Neuroscience 35: 4025-4039.

 
Henkel B, Drose D, Ackels T, Oberland S, Spehr M and Neuhaus EM (2014). Coexpression of Anoctamins in cilia of olfactory sensory neurons. Chemical Senses 40: 73-87.
 

Kaur AW, Ackels T, Kuo T-H, Cichy A, Dey S, Hays C, Kateri M, Logan DW, Marton TF, Spehr M, Stowers L (2014) Murine Pheromone Proteins Constitute a Context-Dependent Combinatorial Code Governing Multiple Social Behaviors. Cell 157, 676–688.

 

Ferrero DM, Moeller LM, Osakada T, Horio N, Li Q, Roy DS, Cichy A, Spehr M, Touhara K, Liberles SD (2013) A juvenile mouse pheromone inhibits sexual behavior through the vomeronasal system. Nature 502: 368-371.

 

Fluegge D, Moeller LM, Cichy A, Gorin M, Weth A, Veitinger S, Cainarca S, Lohmer S, Corrazza S, Neuhaus EM, Baumgartner W, Spehr J, Spehr M (2012) Mitochondrial Ca2+ Mobilization is a key element in olfactory signaling. Nat. Neurosci. 15: 754-762.

 

Veitinger S, Veitinger T, Cainarca S, Fluegge D, Engelhardt CH, Lohmer S, Hatt H, Corrazza S, Spehr J, Neuhaus EM, Spehr M (2011) Mitochondrial Ca2+ Mobilization in Purinergic Mouse Sertoli Cell Signaling. J. Physiol. 589: 5033–5055.

 

Ferrero DM, Lemon JK, FlueggeD, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, Liberles SD (2011) Detection and avoidance of a carnivore odor by prey. PNAS 108: 11235-11240.

 

Rivière S, Challet L, Fluegge D, Spehr M, Rodriguez I (2009) Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors. Nature 459: 574-577.

 

Spehr M and Munger SD (2009) Olfactory receptors: GPCRs and beyond. J. Neurochem. 109: 1570-1583.

 

Hagendorf S, Fluegge D, Engelhardt C, Spehr M (2009). Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels. J. Neurosci. 29: 206-221.

 

Spehr M, Kelliher KR, Li XH, Boehm T, Leinders-Zufall T, Zufall F (2006) Essential role of the main olfactory system in social recognition of MHC class I peptides. J. Neurosci. 26: 1961-1970.

 

Kelliher KR§, Spehr M§, Leinders-Zufall T, Zufall F (2006) Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing. Eur. J. Neurosci. 23: 3385-3390.                    § authors contributed equally

 

Spehr M, Schwane K, Heilmann S, Gisselmann G, Hummel T, Hatt H (2004) Dual capacity of a human olfactory receptor. Current Biology 14: 832-833.

 

Spehr M, Schwane K, Riffell JA, Barbour J, Zimmer RK, Neuhaus EM, Hatt H (2004) Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. J. Biol. Chem. 279: 40194-40203.

 
Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H (2003) Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 299: 2054-2058.  

Spehr M, Hatt H, Wetzel CH (2002) Arachidonic acid plays a role in rat vomeronasal signal transduction. J. Neurosci. 22: 8429-8437.

 

 

Spehr M, Wetzel CH, Hatt H, Ache BW (2002) 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron 33: 731-773.  
 
 
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